<p>Association of <em>IFNL3</em> rs12979860 polymorphism with HCV-related hepatocellular carcinoma susceptibility in a Chinese population</p>
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منابع مشابه
Functional Short Tandem Repeat Polymorphism of PTPN11 and Susceptibility to Hepatocellular Carcinoma in Chinese Populations
BACKGROUND PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Loss of Shp2 promotes hepatocellular carcinoma (HCC), suggesting that PTPN11 functions as a tumor suppressor in HCC tumorgenesis. The aim of this study was to evaluate the effects of the short tandem repeat (STR) polymorphism (rs199618935) within 3'UTR of PTPN11...
متن کاملHepatocellular carcinoma in a sheep
At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...
متن کاملIL28B rs12979860 gene polymorphism in Egyptian patients with chronic liver disease infected with HCV.
BACKGROUND Egypt has one of the highest prevalences of hepatitis C virus (HCV) infection worldwide. Although the IL28B gene polymorphism has been shown to modify the course of chronic HCV infection, this has not been properly assessed in the Egyptian population. MATERIALS AND METHODS The IL28B rs12979860 single nucleotide polymorphism (SNP) was therefore examined in 256 HCV-infected Egyptian ...
متن کاملA Non-Synonymous Single Nucleotide Polymorphism in the HJURP Gene Associated with Susceptibility to Hepatocellular Carcinoma among Chinese.
OBJECTIVE HJURP (Holliday Junction-Recognizing Protein) plays dual roles in DNA repair and in accurate chromosome segregation during mitosis. We examined whether the single nucleotide polymorphisms (SNPs) of HJURP were associated with the risk of occurrence of hepatocellular carcinoma (HCC) among chronic hepatitis B virus (HBV) carriers from well-known high-risk regions for HCC in China. METH...
متن کاملStudying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals
Background & Objective: Hepatitis C Virus (HCV) is one of the important risk factors for liver cirrhosis and hepatocellular carcinoma. Some of the host genetic factors such as interleukin 28B (IL-28B) may influence the response to the antiviral therapy. IL28B is a member of the interferon (IFN) family which causes an antiviral response. Previous studies indicated that rs12979860 polymorphisms o...
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ژورنال
عنوان ژورنال: Clinical and Experimental Gastroenterology
سال: 2019
ISSN: 1178-7023
DOI: 10.2147/ceg.s206194